CROSSTALK BETWEEN ARYL HYDROCARBON RECEPTOR (AHR) AND BCL-2 PATHWAYS SUGGESTS THE USE OF AHR ANTAGONIST TO MAINTAIN NORMAL DIFFERENTIATION STATE OF MAMMARY EPITHELIAL CELLS DURING BCL-2 INHIBITION THERAPY

Introduction: Activating the aryl hydrocarbon receptor upon exposure to environmental pollutants promotes development of breast cancer stem cell (CSCs).BCL-2 family proteins protect cancer cells from the apoptotic effects of chemotherapeutic drugs.However, the crosstalk between AhR and the BCL-2 family in CSC development remains uninvestigated.Obje

Pear scab and rust are the major diseases causing severe epidemics in organic cultivation of pear trees.Incidences of pear scab and rust were compared in organically managed plots sensory play and conventionally managed plots to obtain optimum application schedule of environment-friendly control agents in organically managed plots.Organically cultu

Analyses of information and communication technologies (ICTs) and the internet have underlined, on the one hand, their capacity to enable Military Airplane processes of participation and democratic dynamics and, on the other hand, have criticised certain tendencies to a technological determinism and cyberutopianism regarding this capacity.These deb

Abstract In December 2022, the Ministry of Health, Labour and Welfare (MHLW) of Japan issued and implemented the guideline for evaluating the effects of psychotropic drugs on motor vehicle driving performance.This guideline recommends the use of a tiered approach to assess clinically meaningful driving impairment.It is noted Protection that adverse